The Rubiaceae /ruːbiˈeɪʃiː/ are a family of flowering plants, commonly known as the coffee, madder, or bedstraw family. It consists of terrestrial trees, shrubs, lianas, or herbs that are recognizable by simple, opposite leaves with interpetiolar stipules and sympetalous actinomorphic flowers. The family contains about 13,500 species in about 620 genera, which makes it the fourth-largest angiosperm family. Rubiaceae has a cosmopolitan distribution; however, the largest species diversity is concentrated in the tropics and subtropics. Economically important species include Coffea, the source of coffee, Cinchona, the source of the antimalarial alkaloid quinine, some dye plants (e.g., Rubia), and ornamental cultivars (e.g., Gardenia, Ixora, Pentas).